This was interesting. I like how the characters are both attractive and hideous at the same time (i.e. curvy, exaggerated bodies and "sparkly eyes" combined with pimply faces and bad teeth). I kind of wish the actual Japanese anime industry was less afraid to make less attractive and "marketable" characters, but I could say the same about American animation too after the 1990's. It's like some bizarre combination of Shin-Chan with raunchy children in seemingly-innocent and childlike conversations and situations, Pop Team Epic in that they're basically foul-mouthed teenage girls who are DEFINITELY not old enough to drink and smoke yet, and '90's Nickelodeon (Ren and Stimpy, Ahh! Real Monsters, etc) because again, the characters are some amusing combination of cute and repulsive.
The green-haired girl with the deepest, most demonic voice was amazing.
I also like how the subtitles followed the standard of some of the best fan-subs of classic Japanese anime, in that it has footnotes at the top of the screen explaining cultural puns that outsiders like me wouldn't pick up on and allows the subtitles to otherwise be completely uncensored, unlike so many subbed anime in the US version of Netflix (and the less said about English dubs from 4Kids and Funimation, the better).
One more positive thing, I like how you handled the concept of limited animation here--yes, the characters are mostly just flapping their lips (although it looks like they have proper lip synching instead of just opening and closing constantly), but there are fun moments where they make gloriously stupid faces and body language, and it happens infrequently enough that it is funny and a shock every time it happens--not like, say, the most recent episodes of SpongeBob where the constant funny drawings are seen as a crutch for how boring the writing and jokes have gotten due to being on the air too long.
Perhaps you could get more experimental with the animation, though, if the episodes were shorter? Perhaps the standard (in the US, at least) 22 minutes long at most? I admit that I almost had a heart attack seeing that I had to sit through this for 45+ minutes just to give a proper review, although I'm sure I'm coming across as a hypocrite with this review dragging on.
Finally, though, you've mentioned that you've been trying to turn this into an actual TV series? Can you elaborate on that in a blog post on Newgrounds or something, like, are you making this specifically for Brazil's audience or do you plan on this being released worldwide? I can't speak for Brazil's TV standards, but as much as I personally enjoyed as an American watching something so unabashedly-offensive to both extremes of US politics (the left would not take kindly to the sexist stuff or even the big breasts, while the right would have been triggered by the latter half making fun of the Christian Bible, and both would be absolute prudes about anything sexual in general), I don't know how much success you would have pitching this to a country as notoriously-over-sensitive as the United States. But again, I don't really know your future plans with this series, maybe that last part was a moot point and again, as someone so accustomed to heavily-censored English dubs of anime and "adult" animation mostly just being a lot of gross-out humor I outgrew by my 17th birthday, I did enjoy the unfiltered grossness of this series once I turned off my own sensitive 'Murican part of my brain.
I know you wanted a more candid review from me, so hopefully this gives you some more direction on where to take this series next!